Emerging Infectious Diseases, 29(10), 1979-1989.Įffects of COVID-19 on Maternal and Neonatal Outcomes and Access to Antenatal and Postnatal Care, Malawi Posttransfusion Sepsis Attributable to Bacterial Contamination in Platelet Collection Set Manufacturing Facility, United States. H., Gable, P., Annambhotla, P., McAllister, G.Basavaraju, S. Kracalik I, Kent AG, Villa CH, Gable P, Annambhotla P, McAllister G, et al. Clinicians should maintain awareness of possible transfusion-transmitted sepsis even when using bacterial risk control strategies. Whole-genome sequencing showed environmental isolates from the manufacturer were closely related genetically to patient and platelet isolates, indicating the manufacturer was the most probable source of recurrent polymicrobial contamination. saprophyticus in 4 patients and 4 transfused platelets. Cultures identified Acinetobacter calcoaceticus‒baumannii complex in 6 patients and 6 transfused platelets, S. Seven sepsis cases from 6 platelet donations from 6 different donors were identified in patients from 6 states 3 patients died. Environmental samples were collected from a platelet collection set manufacturing facility. Transfused platelet components underwent bacterial risk control strategies (primary culture, pathogen reduction or primary culture, and secondary rapid test) before transfusion. An aggressive and universal program involving surveillance and isolation will be needed to control the spread of CRKP in the city of New York.ĭuring May 2018‒December 2022, we reviewed transfusion-transmitted sepsis cases in the United States attributable to polymicrobial contaminated apheresis platelet components, including Acinetobacter calcoaceticus‒baumannii complex or Staphylococcus saprophyticus isolated from patients and components. Most patients with metallo-β-lactamases originated from long-term care facilities. After 2020, a marked increase occurred in the percentage of isolates possessing metallo-β-lactamases. The remaining 39 cases were proven or presumptive metallo-β-lactamases all confirmed cases were New Delhi metallo-β-lactamases. Of 182 isolates with proven or presumptive (ceftazidime/avibactam susceptible) enzymes, 143 were serine carbapenemases most confirmed cases were K. Of 509 cases, 262 (51%) were considered community-onset, including 149 in patients who were living at home. During 2016–2020, CRKP cases declined however, during 2021–June 2022, a notable increase occurred. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA. In 2020–2022, a total of 68.2% IPD cases were potentially covered by PCV20.Ĭontrolling the spread of carbapenem-resistant Enterobacterales is a global priority. Percentages of serotype 3 and 8 IPD increased, and 19F and 19A reemerged. However, residual PCV13 serotype IPD remained, representing 21.7% of 2021–2022 cases, indicating that major adult PCV serotype disease still occurs despite 17 years of pediatric PCV use. Disease severity changed throughout this period: CURB65 severity scores and inpatient deaths decreased and ICU admissions increased. IPD decreased during the early COVID-19 pandemic but during 2022 gradually returned to prepandemic levels. Of those cases, 1,686 were invasive pneumococcal disease (IPD) 1,501 (89.0%) had a known serotype. We report serotype and disease severity trends in 3,719 adults hospitalized for pneumococcal disease in Bristol and Bath, United Kingdom, during 2006–2022. Ongoing surveillance after pneumococcal conjugate vaccination (PCV) deployment is essential to inform policy decisions and monitor serotype replacement.
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